Intermittent bacteremia detected in an asymptomatic apheresis platelet donor with repeat positive culture for <i>Escherichia coli</i>: a case report
Bibliographic record
Abstract
BACKGROUND: Bacterial culture of platelet concentrates (PCs) has been implemented to reduce the risk of infectious transfusion events. Most positive cultures are for skin flora or environmental organisms with no underlying pathology associated in the donor. Less frequently, enteric organisms have been isolated from PCs indicating asymptomatic donor bacteremia. We report a case of a donor with repeat positive culture for Escherichia coli. CASE REPORT: A 62-year-old single apheresis platelet (PLT) donor who passed all routine screening procedures had two intermittent positive BacT/ALERT cultures with E. coli. On both occasions, transfusion was prevented with the contaminated units. The donor denied any symptoms suggestive of infection and was referred to his family physician for evaluation. A barium enema revealed multiple colonic diverticula, although the donor has remained asymptomatic. Based on his history of repeat-positive cultures with the same enteric organism, the donor has been permanently deferred. DISCUSSION: PLT screening for bacterial contamination has been an effective measure to reduce the incidence of septic transfusion reactions. Important is the capture of Gram-negative bacteria, which can be involved in septic shock due to the production of endotoxins. In addition to the safety benefit to PLT recipients, PLT culture is valuable for blood donors. The recurrence of positive cultures with the same organism allows the identification of subclinical illnesses and, if appropriate, deferral from blood donation. CONCLUSION: This asymptomatic donor has intermittent bacteremia likely related to diverticular disease. Isolation of E. coli twice prompted further investigation and donor deferral.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.002 | 0.002 |
| Meta-epidemiology (broad) | 0.002 | 0.002 |
| Bibliometrics | 0.003 | 0.002 |
| Science and technology studies | 0.003 | 0.002 |
| Scholarly communication | 0.003 | 0.002 |
| Open science | 0.002 | 0.002 |
| Research integrity | 0.006 | 0.005 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".