Quality of life in adolescents with recently diagnosed childhood-onset systemic lupus erythematosus
Bibliographic record
Abstract
A preliminary sample of twenty cSLE subjects (Mean Age 14.9 ± 2.3 years, 75% female) and their parents completed standardized questionnaires assessing quality of life (PedsQL) and depression (Children’s Depression Inventory, CDI) as part of an observational research study of neurocognitive function in cSLE patients within 18 months from diagnosis of cSLE. Correlations and repeated measures ANOVA were used to examine parent-youth agreement and associations between QoL domains and depressive symptoms. PedsQL scaled scores were calculated for each domain, with higher scores representing greater health-related QoL (range 0 - 100). Both cSLE subjects and their parents reported lower QoL scores in the adolescent’s physical, emotional and school functioning as compared to social functioning, which remained relatively less affected (mean scaled scores 67.0, 61.7, 63.9 and 82.6 respectively, p <.001). Mean CDI scores were within the normal range, with 3 subjects (15%) scoring in the depressive symptom range. Depressive symptoms were strongly correlated with the emotional difficulties domain for both the cSLE self-report ( r = -0.73, p <.01) and for the parent report ( r = -0.84, p <.01). Similarly, depressive symptoms were correlated with the physical challenges domain for both cSLE self-report ( r = -0.61, p < .05) and parent report ( r = -0.50, p <.05), and their reported problems at school ( r = -0.61, p < .01). In this preliminary report we found that cSLE affects not only physical functioning domain of QoL early on, but also the domains of emotional and school functioning, within months of diagnosis. Not surprisingly, symptoms of depression were associated with multiple aspects of quality of life, including emotional, school and physical functioning. Further study will examine for associations of QoL with neurocognitive function.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".