A Multi-Targeted Antisense Oligonucleotide-Based Therapy Directed at Phosphodiesterases 4 and 7 for COPD
Bibliographic record
Abstract
Recent drug development for chronic obstructive pulmonary disease (COPD) has focused on strategies aimed at reducing the underlying inflammation by selective inhibition of phosphodiesterases (PDE), specifically the PDE4 isoforms. The anti-inflammatory and bronchodilator activities of PDE4 inhibitors have been well documented (Giembycz &Field 2010), however their clinical development has been hampered by their low therapeutic ratio and dose-dependent systemic side effects. PXS TPI1100 is an inhaled drug candidate consisting of two modified antisense oligonucleotides (AON) directed at PDE isoforms 4B, 4D and 7A. PXS TPI1100 has been designed to reduce the recruitment and persistence of inflammatory cells in COPD through an unique mechanism of action and has the potential to be a novel, highly effective approach for this respiratory disease.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".