Anaphylaxis associated with folic acid: domestic case review
Bibliographic record
Abstract
Synthetic folic acid has been shown to cause serious, potentially life-threatening IgE mediated anaphylaxis [ 1 – 3 ]. Synthetic folic acid does not occur naturally and is distinct from naturally occurring folic acid [ 1 , 4 , 5 ]. A search of the Canada Vigilance Database from April 1, 2008 to August 31, 2013 identified 15 cases of anaphylaxis and 16 reports of serious non-anaphylactic allergic reactions. All 15 cases of anaphylaxis involved multi ingredient products with NHP doses (up to and including 1 mg). Fourteen cases were female (93%). One case of anaphylaxis and 3 cases of serious allergic reaction involved women taking prenatal supplements, two of which reported spontaneous abortion. There was insufficient case information available to assess any causal association between the allergic reaction and the fetal loss. Three medically important cases involved pharmaceutical doses of folic acid (5 mg), one of which was a pediatric case involving a multi ingredient intravenous total parental nutrition product (Multi-12/K1 pediatric) containing folic acid. Confirmatory allergy tests for folic acid were not available for any of the cases. None of the reports noted a known diagnosis of folic acid allergy. Folic acid allergy appears to be rare and would not be expected to be well known among health providers or consumers. Increasing awareness amongst health providers regarding folic acid allergy may improve the identification and counselling of patients with this allergy.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.005 | 0.004 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.002 |
| Open science | 0.002 | 0.002 |
| Research integrity | 0.004 | 0.002 |
| Insufficient payload (model declined to judge) | 0.005 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".