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Record W1505939010 · doi:10.5772/32006

Primary Prevention of Neural Tube Defects

2012· book-chapter· en· W1505939010 on OpenAlexaboutno aff
Claudine Nasr, Grace Abi

Bibliographic record

VenueInTech eBooks · 2012
Typebook-chapter
Languageen
FieldMedicine
TopicFolate and B Vitamins Research
Canadian institutionsnot available
Fundersnot available
KeywordsNeural tubeTube (container)Primary (astronomy)Primary preventionMedicineMaterials scienceInternal medicineBiologyComposite materialPhysics

Abstract

fetched live from OpenAlex

Studies had proven that supplementation of women of childbearing age with folic acid can prevent up to 70% of all cases of NTDs (Laurence et al 1981, MRC Vitamin Study Research Group 1991). These researches led to international recommendations that all women of childbearing age consume 400 micrograms of folic acid daily for the prevention of neural tube defects at least 1 month before and throughout the first trimester of pregnancy (CDC 1992, Institutes of Medicine 1998, WHO 2002). Three potential approaches were advocated to increase level of folic acid consumption among the general population: fortification of food supply, improvement of dietary habits and use of dietary supplements (CDC, 1992). In some countries such as Canada and the USA, these recommendations led to the fortification of all enriched grain products with folic acid. This action decreased the occurrence of spina bifida by 31% and anencephaly by 16% (CDC 2004) and thus was considered as a partial success. As for the change in eating habits, meeting dietary recommendations for grain intake is an important step to achieving the recommended daily intake for folic acid. Studies have shown that non pregnant women of childbearing age reported an average daily consumption of 128 mcg of folic acid, representing only 32 percent of the daily recommended amount (Yang et al. 2007). These facts imply that most women still need to daily consume a dietary supplement containing folic acid at the recommended dose (400 μg) in order to prevent pregnancies with NTDs. Despite all this, several studies have shown a low consumption of folic acid supplements worldwide: numbers vary from prevalence as low as 7.5% in Lebanon (Nasr Hage et al 2011) to the highest percentage of 40 % in Canada and the USA (Morin et al. 2002; Petrini et al, 2008). These percentages remain far from the “Healthy people 2010” goal aiming that a minimum of 80% of women of childbearing age consume at least 400 mcg of folic acid daily in the periconception period. Levels of awareness and knowledge have been studied extensively in women of childbearing age in order to explain the low prevalence of folic acid intake with variable results in different countries. Although these levels of awareness and knowledge were thought to explain low levels of folic acid consumption, a systematic review of the literature showed that variable interventions on folic acid increased women’s awareness from 60% to 72% and knowledge

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Other · Consensus signal: Other
Teacher disagreement score0.529
Threshold uncertainty score0.795

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.043
GPT teacher head0.306
Teacher spread0.263 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreOther

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2012
Admission routes1
Has abstractyes

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