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Record W1508001280 · doi:10.1002/9780470514597.ch9

A Non‐Photic Gateway to the Circadian Clock of Hamsters

2007· review· en· W1508001280 on OpenAlex
N. Mrosovsky

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueNovartis Foundation symposium · 2007
Typereview
Languageen
FieldNeuroscience
TopicCircadian rhythm and melatonin
Canadian institutionsUniversity of Toronto
Fundersnot available
KeywordsSuprachiasmatic nucleusNeuroscienceNeuropeptide Y receptorPhase response curveCircadian rhythmHamsterNoveltyPhotic zoneBiologyNeuropeptideHypothalamusCircadian clockEndocrinologyInternal medicinePsychologyMedicineReceptorGenetics

Abstract

fetched live from OpenAlex

This paper considers the neural mechanisms underlying a particular kind of non-photic phase shifting, that produced by novelty-induced wheel running in the hamster. The projection from the intergeniculate leaflet (IGL) to the suprachiasmatic nucleus (SCN) appears to be an important part of the mechanism mediating such phase shifts. A number of experiments support this view. First, expression of immediate-early genes in the IGL is induced by non-photic phase-shifting stimuli. Second, Fos-like immunoreactivity in the IGL co-localizes with neuropeptide Y (NPY) immunoreactivity. Third, direct application of NPY to the SCN produces phase shifts which do not depend on the hamsters becoming active following the injections. Fourth, blocking the normal actions of NPY at the SCN blocks or greatly attenuates the phase shifting that is normally produced by novelty-induced wheel running. Progress on the physiological basis of phase shifts associated with activity, or a correlate, depends on understanding the behavioural aspects of this phenomenon. The activity-shift response curve is especially useful.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Insufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.991
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0010.002
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.004

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.079
GPT teacher head0.345
Teacher spread0.266 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it