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Record W1511996081 · doi:10.1002/wmts.87

Connexins, gap junctions, and glia

2013· article· en· W1511996081 on OpenAlexaff
Christian Giaume, Christian C. Naus

Bibliographic record

VenueWiley Interdisciplinary Reviews Membrane Transport and Signalling · 2013
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicConnexins and lens biology
Canadian institutionsUniversity of British Columbia
Fundersnot available
KeywordsGap junctionOligodendrocyteMicrogliaCell biologyNeuroscienceBiologyNeurogliaAstrocyteCentral nervous systemMyelinImmunologyIntracellularInflammation

Abstract

fetched live from OpenAlex

Neurons and glial cells are the two main classes of cells present in brain. There are four classes of glial cells in the brain that differ by their origin, morphology, and function: microglia, oligodendrocytes, NG2 (nerve/glia antigen 2) cells, and astrocytes. Microglial cells, which are derived from the mesoderm, represent approximately 10% of glia and are the resident immune cells of the central nervous system ( CNS ). Three subclasses compose the macroglia and are derived from the ectoderm. As an overview one can consider that: (1) the oligodendrocytes are mainly involved in the myelination of axons, (2) the NG2 cells comprise oligodendrocyte precursor cells but they are also multipotential cells, although this issue is still debated, and (3) finally, astrocytes are the predominant glial cells in the brain that establish active interactions with neurons and the vascular system. With the exception of NG2 cells, all glial cells are characterized by the expression of gap junction proteins (connexins) with specific features and properties. In addition, a number of neuropathological disorders involve changes in Cx expression and channel function. WIREs Membr Transp Signal 2013, 2:133–142. doi: 10.1002/wmts.87 Conflict of interest: The authors have declared no conflicts of interest for this article. For further resources related to this article, please visit the WIREs website .

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.920
Threshold uncertainty score0.939

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.020
GPT teacher head0.263
Teacher spread0.243 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations23
Published2013
Admission routes1
Has abstractyes

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