Clinical and MRI Phenotype of Children with MOG Antibodies (P2.240)
Bibliographic record
Abstract
OBJECTIVE: To identify the clinical and MRI phenotype of MOG antibody seropositive children with demyelinating diseases. BACKGROUND: There is limited information about the clinical relevance of MOG antibodies in children. DESIGN/METHODS: 171 total serum samples from 83 children with demyelinating diseases followed at the Partners Pediatric MS Center, Massachusetts General Hospital, were studied. MOG antibodies were detected using cell-based assay previously described (McLaughlin, Journal of Immunology 2009 15;183(6):4067-76). Binding ratio of >5 was considered positive. 21 healthy control children were included. Clinical data was gathered from a longitudinal electronic database. Lesion locations were tabulated from brain and cervical-thoracic MRIs. RESULTS: 13/83 children were seropositive for MOG antibodies at first blood draw, and included children with a diagnosis of MS (n=4), CIS (n=2), ADEM (n=3), NMO (n=2) and other demyelinating disease (n=2). Seropositive patients were younger than seronegative patients at first symptom-onset (9.94 vs. 13.71 years p=0.004), but did not differ by gender. There was a significant difference in disease category with more seronegative patients being categorized as MS or CIS. P=0.009. Optic nerve first attack location was significantly higher in the seropositive than seronegative patients (62% vs. 28% p=0.023, Fisher’s Exact Test); encephalopathy at first symptom was more frequent in seropositive patients (31% vs. 7%, p=0.030). EDSS at blood draw or longitudinal change in EDSS did not differ between the two groups. Brain MRI analysis showed that corpus callosum lesions were present only in seronegative patients (p=0.012). Thoracic lesions were present in 17/50 seronegative patients, but not in seropositive patients (p=0.091). There was no difference in the proportion with LETM. In patients with longitudinal samples, 1 was always positive (RRMS), 4 switched from positive to negative antibody status and 7 switched from negative to positive. CONCLUSIONS: Clinical and MRI features distinguish MOG antibody seropositive children. Study Supported by: Fundacion Caja-Madrid (Spain), National MS Society
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".