ILC2 + DC = Th2, group 2 innate lymphoid cell derived IL-13 is essential for efficient T helper 2 cell differentiation in allergic lung inflammation. (HYP6P.258)
Bibliographic record
Abstract
Abstract Naïve CD4+ T cell differentiation into distinct subsets of T helper (Th) cells is a pivotal process in the initiation of the adaptive immune response. Allergens predominantly stimulate Th2 cells, causing allergic inflammation. However, why allergens induce Th2 cell differentiation is not understood. Here we show that Group 2 Innate Lymphoid Cells (ILC2) are required to mount a robust Th2 cell response to the protease-allergen papain. Intranasal administration of papain stimulates ILC2 and Th2 cells, causing allergic lung inflammation and elevated IgE titre. This process is severely impaired in ILC2-deficient mice. More careful analysis reveals that ILC2 derived IL-13 is important for Th2 cell differentiation. Adoptive transplant of WT but not IL-13KO ILC2s restores the Th2 response. Recombinant IL-13 administration also rescues the Th2 defect in ILC2-deficient mice. Notably, intranasal IL-13 + OVA injection efficiently drives Th2 skewing of OTII transgenic T cells. Mechanistically, we show that IL-13 has a profound effect on homing of dendritic cells to the draining lymph-node, where they prime naïve CD4+ T cells. Lung explant from IL-13KO mice cultured in a transwell system show severely impaired DC migration to lymph-node homing chemokine gradients. Moreover, these processes require IL-33-dependent ILC2 activation, which suggests a common pathway in the initiation of the Th2 response to allergens.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".