A novel role for blood endothelial cells in the development and maintenance of immune memory (110.17)
Bibliographic record
Abstract
Abstract Vaccination with recombinant human adenovirus serotype 5 (rHuAd5) drives a CD8+ T cell response that is dominated by effector and effector memory cells. In investigating the immunobiological mechanisms that result in this effector-skewed response, we previously showed that non-haematopoietic cells play a key role in defining the rHuAd5-elicited CD8+ T cell memory population. Furthermore, maintenance of this memory population relies upon sustained transgene expression from the adenovirus vector. While we know that following vaccination rHuAd5 drains to local lymph nodes, long-term antigen persistence occurs outside this location, since surgical removal of these nodes does not impact the nature of the memory response. Here, we show that following intramuscular vaccination, the adenovirus transgene is predominantly detected in the perinodal adipose tissue, in addition to draining lymph nodes and the muscle injection site itself. In all three locations, blood endothelial cells are the primary cell type that express the adenovirus-encoded antigen, strongly indicating that this radio-resistant cell population may have a role in presenting antigen to CD8+ T cells and ultimately in defining the memory response. Long-term antigen presentation from this cell compartment may represent a mechanism to sustain CD8+ T cell memory within the circulation and to ensure adequate protective immunity is maintained in multiple organs.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".