Localised prostate cancer treated with MRI-guided transurethral ultrasound ablation: phase I trial results
Why this work is in the frame
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Bibliographic record
Abstract
Enrolled were 30 patients with biopsy-proven, low-risk prostate cancer (age ≥ 65y, T1c/T2a, PSA ≤ 10ng/ml, Gleason 6 (3+3)). Whole-gland prostate ablation was performed with MR-TULSA using the PAD-105 (Profound Medical Inc., Canada) and a 3T MRI (Siemens, Germany) in one single treatment session under general anaesthesia and 3D active MR-thermometry feedback control. Contrast-enhanced MRI (CE-MRI) immediately following the ablation and at 12 months confirmed thermal coagulation. There were no intraoperative complications with normal micturition resuming after catheter removal. Median (range) treatment time and prostate volume were 36 (24–61) min and 44 (21– 95) ml, respectively. Maximum temperature during treatment depicted a continuous region of heating shaped accurately to the prostate within 0.1 ± 1.3 mm, with average over- and under- targeted volumes of 0.8 and 1.0 ml, respectively. Regions of acute cell kill on CE-MRI correlated well with treated volume on MR-thermometry. Successful treatment was further confirmed by a median PSA decrease from 5.35 to 0.70 ng/ml at 1 month (n=29), remaining stable to 0.65 ng/ml at 6 months (n=16). Phase I results show that MR-TULSA represents a minimally-invasive treatment option for safe, effective and accurate whole-gland thermal ablation of organ-confined prostate cancer.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it