Abstract 17212: Effect of Enalapril on Long-Term Survival among Patients with Left Ventricular Systolic Dysfunction: a 25-Year Near-Full Life-Cycle Follow-Up of SOLVD in Belgium
Bibliographic record
Abstract
BACKGROUND: We previously reported that in-trial enalapril therapy was associated with a post-trial mortality benefit in a 12-year follow-up of the Studies of Left Ventricular Dysfunction (SOLVD). We reported here the effect of enalapril on long-term survival in a SOLVD cohort from Belgium that had reached a near-full life-cycle follow-up after 25 years. METHODS: Among the 558 Belgium patients originally enrolled in SOLVD (398 in prevention arm and 160 in treatment arm), post-trial mortality data were prospectively collected on all 433 survivors (218 in enalapril group vs. 215 in placebo group) at closeout. All patients received enalapril therapy after the trial ended. RESULTS: No patients were lost to follow-up. The median duration of follow-up was 25.3 years since randomization or 22.1 years since closeout. In all, 91% of patients had died. Kaplan-Meier event rate for all-cause mortality was lower in the enalapril group than the placebo group over the entire follow-up period (88% vs. 94%, p=0.02). When ...
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".