Isoflurane anesthesia for status asthmaticus: 10 years' experience
Bibliographic record
Abstract
Twenty-six of 47 patients (age 40 ± 20 years; 40 females) admitted to our ICU required MV. Cause for asthma exacerbation was infection in 57% of patients. Admission respiratory and heart rate, mean blood pressure, PO 2 , PCO 2 and pH was 37 ± 14, 127 ± 22 bpm 100 ± 23 mmHg, 133 ± 101 torr, 48 ± 29 torr, and 7.30 ± 0.18, respectively. Six of 26 patients received ISO (dose, 84 ± 106 MAC hours) for 87 ± 109 hours (range 8–227 hours). Hypotension occurred in all ISO patients and in one non-ISO patient, who was adequately treated with fluid (100%), and one inotrope in 3/6 ISO patients. Continuous paralysis was required in five patients. Patients who received ISO required a longer duration of MV and ICU length of stay (LOS) (Table 1 ). There were no pneuomothoraces, air embolism or significant hypoxia in any patient. Five patients received sodium bicarbonate infusions for acidosis. Three patients in the ISO group died: one anoxic encephalopathy (VSA arrest prior to admission), one withdrawal of life support due to comorbid diseases, and one cardiac arrest (cause unknown). Two patients died in the non-ISO group; one anoxic encephalopathy (VSA arrest prior to admission) and one withdrawal of life support (comorbid diseases). None died due to failure to oxygenate/ventilate. Inhalational isoflurane anesthesia is a useful bronchodilator therapy in patients with severe exacerbations of asthma and should be considered in patients who do not respond adequately to conventional bronchodilator therapy.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".