CD40 Ligand and Its Receptors in Atherothrombosis
Bibliographic record
Abstract
Atherothrombosis 80 2. The CD40L system 2.1 CD40L CD40L, also known as CD154, is a 39 kDa transmembrane protein belonging to the tumor necrosis factor (TNF) superfamily originally identified on cells of the immune system. e interaction of CD40L with its respective receptor on B cells, CD40, a glycoprotein also from the TNF receptor (TNFR) family, is of critical importance for immunoglobulin isotype switching during the immune response. The importance of this interaction is highlighted by the pathophysiological manifestations seen in patients suffering from the X-linked hyperimmunoglobulin-M syndrome, in which B-cells fail to produce the immunoglobulin's IgG, IgA and IgE as a consequence of a genetic mutation in the CD40L gene. Because of its wide distribution across cells of the vascular system (endothelium, B and T lymphocytes, neutrophils, platelets, monocytes, dentritic cells and smooth muscle cells), the CD40L/CD40 dyad also shares important implications in cell-mediated immunity. 7]
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".