Association of Filaggrin (FLG) Gene Polymorphism with Canine Atopic Dermatitis in Small Breed Dogs
Bibliographic record
Abstract
As a cornified envelope protein, filaggrin (FLG) is involved in the formation and support of the skin barrier.FLG single nucleotide polymorphism (SNP) at the position 64,297,022 (rs22588227) on canine chromosome 17 hasinitially been described as being associated with canine atopic dermatitis (CAD) in Labrador Retrievers in UK. In thisstudy, we have examined whether the mentioned FLG SNP is associated with a susceptibility to CAD in small breeddogs, comprising 21 Poodles, 17 Shih tzus and 3 Pugs. Twelve of these subjects were dogs with atopy and wereassigned to the experiment group and the remaining 39 samples were healthy controls. The results showed nodifference of the allele frequencies at the above-mentioned position between dogs with atopic dermatitis and thecontrols. However, this study assessed a naturally observed sequence diversity of FLG in the dog, identifying 13 newSNPs within canine FLG and a novel repeated sequence of FLG which had not appeared in dog genome databases.Allele frequencies demonstrated that 2 of the 13 novel observed polymorphisms at the locations 64,297,000 (p = 0.041,odds ratio = 3.920) and 64,297,126 (p = 0.043, odds ratio = 3.706) were plausibly associated with a susceptibility toCAD. The effect of all SNPs was dependent on one another with a strong linkage disequilibrium (D’≥0.89) in onehaplotype block (frequencies ≥2%). This study suggests a role of FLG polymorphisms in CAD and also demonstratesthe successful attempts to identify another unique fragment of the repeated FLG sequence and the novel SNPs.However, since small population was included in this study, the study should be repeated with a larger population.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".