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Record W1538399159 · doi:10.1002/cphy.cp020110

The Cardiac Na<sup>+</sup>‐Ca<sup>2+</sup>Exchanger

2002· other· en· W1538399159 on OpenAlexaff
Larry V. Hryshko

Bibliographic record

VenueComprehensive physiology · 2002
Typeother
Languageen
FieldMedicine
TopicCardiac electrophysiology and arrhythmias
Canadian institutionsUniversity of ManitobaSt. Boniface Hospital
Fundersnot available
KeywordsSodium-calcium exchangerChemistryIon exchangeBiophysicsIon transporterBiochemistryIntracellularBiologyIonMembrane

Abstract

fetched live from OpenAlex

The sections in this article are: 1 A Brief Historical Perspective and Prelude to the Review 2 Physiological Role of The Cardiac Na+-Ca2+ Exchanger 3 Reverse Na+-Ca2+ Exchange as A Trigger for SR Ca2+ Release 4 Digitalis Effects 5 Immunolocalization 6 Transport Properties 6.1 Stoichiometry 6.2 Transport Mechanism 6.3 Turnover Rates and Exchanger Density 6.4 Ion Selectivity 6.5 Temperature Dependence 7 Molecular Biology of the Na+-Ca2+ Exchanger 7.1 The Prototypical Canine Cardiac Na+-Ca2+ Exchanger 7.2 The Exchanger Superfamily 7.3 Topology of the Na+-Ca2+ Exchanger 7.4 The Calx-α and Calx-β Repeats 7.5 Alternative Splicing of Na+-Ca2+ Exchangers 8 Regulation of Na+-Ca2+ Exchange 8.1 Ionic Regulation 8.1.1 Nai+-Dependent Inactivation 8.1.2 Cai+-Dependent Regulation 8.2 Structure–Function Relationships of Ionic Regulation 8.2.1 The XIP Region 8.2.2 The Regulatory Ca2+ Binding Site 8.3 Regulation by Phosphorylation 8.4 Regulation by PIP2 8.5 Regulation by pH 8.6 Cytoskeletal Interactions 9 Pharmacology of Na+-Ca2+ Exchange 9.1 The Exchanger Inhibitory Peptide, XIP 9.2 Other Peptide Inhibitors 9.3 KB-R7943 9.4 Other Inhibitors 10 Studies in Transgenic Mice 11 Adenoviral Transfection of Na+-Ca2+ Exchange Proteins 12 Antisense Oligonucleotides 13 Frequency-Dependent Behavior of Na+-Ca2+ Exchange 14 Developmental Changes 15 Species Differences 16 Pathophysiological Alterations in Na+-Ca2+ Exchange 16.1 Contribution of Na+-Ca2+ Exchange to Cardiac Injury 16.2 Alterations in Na+-Ca2+ Exchange Levels 17 Summary

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Research integrity, Insufficient payload (model declined to judge)
Consensus categoriesInsufficient payload (model declined to judge)
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Other · Consensus signal: Other
Teacher disagreement score0.313
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0030.001
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0040.006

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.017
GPT teacher head0.257
Teacher spread0.240 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; both teacher heads agree on what is shown here.

Study designNot applicable
Domainnot available
GenreOther

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations17
Published2002
Admission routes1
Has abstractyes

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