MétaCan
Menu
Back to cohort
Record W1538399159 · doi:10.1002/cphy.cp020110

The Cardiac Na<sup>+</sup>‐Ca<sup>2+</sup>Exchanger

2002· other· en· W1538399159 on OpenAlexaff
Larry V. Hryshko

Bibliographic record

VenueComprehensive physiology · 2002
Typeother
Languageen
FieldMedicine
TopicCardiac electrophysiology and arrhythmias
Canadian institutionsUniversity of ManitobaSt. Boniface Hospital
Fundersnot available
KeywordsSodium-calcium exchangerChemistryIon exchangeBiophysicsIon transporterBiochemistryIntracellularBiologyIonMembrane

Abstract

fetched live from OpenAlex

The sections in this article are: 1 A Brief Historical Perspective and Prelude to the Review 2 Physiological Role of The Cardiac Na+-Ca2+ Exchanger 3 Reverse Na+-Ca2+ Exchange as A Trigger for SR Ca2+ Release 4 Digitalis Effects 5 Immunolocalization 6 Transport Properties 6.1 Stoichiometry 6.2 Transport Mechanism 6.3 Turnover Rates and Exchanger Density 6.4 Ion Selectivity 6.5 Temperature Dependence 7 Molecular Biology of the Na+-Ca2+ Exchanger 7.1 The Prototypical Canine Cardiac Na+-Ca2+ Exchanger 7.2 The Exchanger Superfamily 7.3 Topology of the Na+-Ca2+ Exchanger 7.4 The Calx-α and Calx-β Repeats 7.5 Alternative Splicing of Na+-Ca2+ Exchangers 8 Regulation of Na+-Ca2+ Exchange 8.1 Ionic Regulation 8.1.1 Nai+-Dependent Inactivation 8.1.2 Cai+-Dependent Regulation 8.2 Structure–Function Relationships of Ionic Regulation 8.2.1 The XIP Region 8.2.2 The Regulatory Ca2+ Binding Site 8.3 Regulation by Phosphorylation 8.4 Regulation by PIP2 8.5 Regulation by pH 8.6 Cytoskeletal Interactions 9 Pharmacology of Na+-Ca2+ Exchange 9.1 The Exchanger Inhibitory Peptide, XIP 9.2 Other Peptide Inhibitors 9.3 KB-R7943 9.4 Other Inhibitors 10 Studies in Transgenic Mice 11 Adenoviral Transfection of Na+-Ca2+ Exchange Proteins 12 Antisense Oligonucleotides 13 Frequency-Dependent Behavior of Na+-Ca2+ Exchange 14 Developmental Changes 15 Species Differences 16 Pathophysiological Alterations in Na+-Ca2+ Exchange 16.1 Contribution of Na+-Ca2+ Exchange to Cardiac Injury 16.2 Alterations in Na+-Ca2+ Exchange Levels 17 Summary

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Other · Consensus signal: none
Teacher disagreement score0.003
Threshold uncertainty score0.010

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0000.001
Scholarly communication0.0010.002
Open science0.0000.001
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0030.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.017
GPT teacher head0.257
Teacher spread0.240 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreOther

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations17
Published2002
Admission routes1
Has abstractyes

Explore more

Same venueComprehensive physiologySame topicCardiac electrophysiology and arrhythmiasFrench-language works237,207