Endogenous Erythropoietin is a Sex Specific Respiratory Stimulant in Newborn and Adult Mice.
Bibliographic record
Abstract
We hypothesized that endogenous brain Erythropoietin (Epo) is a sex‐specific respiratory stimulant in newborn (10 days old) and adult (3 months) mice. Mice received an intracisternal injection of soluble Epo receptor (sEpoR – antagonist of EpoR) or control. 24 hours after injection, we used whole body plethysmography to record respiratory frequency (fR), tidal volume (V T ), and minute ventilation (V E =fRxV T ), O 2 consumption (VO 2 ) and CO 2 production (VCO 2 ) under normoxia and exposure to moderate (12‐10% O 2 ) and severe hypoxia (6% O 2 ) – 10 minutes each. In normoxia, sEpoR decreased V E in adult and newborn mice, but this effect was sex‐specific as sEpoR decreased fR in females and Vt in males. The ventilatory response to moderate hypoxia (assessed as V E /VO 2 or V E /VCO 2 ) is decreased in newborn male and female mice after injection of sEpoR, but in adult mice this effect was present only in males. During severe hypoxia, newborn male and female mice treated with sEpoR show signs of respiratory depression and asphyxia (gasping). We conclude that endogenous Epo is a potent endogenous respiratory stimulant in newborn and adult mice, that sex‐specific effects are present under normoxic conditions in newborn and adult mice, and that under hypoxic exposure, sex‐specific effects are present only in adult mice. Funded by CIHR (mop: 130258).
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".