Ursolic acid, a promising dietary bioactive compound of anti‐obesity (1045.40)
Bibliographic record
Abstract
Ursolic acid has recently been reported to possess a promising anti‐obesity effect. A number of studies have been conducted to elucidate the underlying mechanisms, which include the inhibition of pancreatic lipase activity, promotion of muscle hypertrophy, increase of brown fat, thermogenesis, energy expenditure, and lipolysis. Our recent study in 3T3‐L1 preadipocytes has demonstrated that ursolic acid inhibits cell differentiation and adipogenesis. This compound modulates the expression or activity of many proteins or enzymes involved in fat cell differentiation, fatty acid synthesis and oxidation. Further studies have shown that ursolic acid increases the phosphorylation and activity of AMPK and the protein expression of Sirt1. The anti‐adipogenic effect of UA can be reversed by AMPK siRNA but not Sirt1 inhibitor. Moreover, when LKB1 is silenced or inhibited, the effect of UA on AMPK activation diminishes. These results demonstrate that ursolic acid inhibits preadipocyte differentiation and adipogenesis through LKB1/AMPK pathway. While focusing on our recent report on the effect and mechanism of action of ursolic acid on fat cell differentiation and adipogenesis, other mechanisms related to energy and fat metabolism and body weight will be briefly discussed. Grant Funding Source : CIHR
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".