Abstract 18482: Pharmacokinetics and Pharmacodynamics of Dabigatran Etexilate in Adolescents: An Open-label Phase IIa Study
Bibliographic record
Abstract
Introduction: Dabigatran etexilate (DE) is an oral direct thrombin inhibitor. It is approved for multiple indications in adults. HYPOTHESIS: To investigate the pharmacokinetics (PK) and pharmacodynamics (PD) of dabigatran in adolescents with venous thromboembolism (VTE). METHODS: Patients aged 12-< 18 years, who had completed anticoagulation treatment with low molecular weight heparin or an oral anticoagulant for VTE as required for clinical management, received DE twice daily for 3 days at exploratory doses targeting 1.71 mg/kg for the first dose, followed by 5 doses of 2.14 mg/kg, if there were no safety concerns. Blood samples for PK/PD purposes were taken at peak (2 h after morning dose) and trough (12 h after the evening dose). Observed plasma concentrations of total dabigatran were compared to simulated concentrations based on a population-pharmacokinetic (PopPK) model. The PK/PD relationships between total dabigatran plasma concentrations and activated partial thromboplastin (aPTT), diluted thrombi...
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".