Reconstitution of protective immune responses against CMV and VZV does not require disease development in paediatric recipients of umbilical cord blood transplantation. (126.4)
Bibliographic record
Abstract
Abstract Cytomegalovirus (CMV) and varicella-zoster virus (VZV) are significant causes of morbidity and mortality following umbilical cord blood transplant (UCBT). Yet the kinetics of reconstitution and protective potential of antiviral cell-mediated immune responses following UCBT remain poorly characterized. Here, the reconstitution of CMV and VZV-specific T cell responses was assessed from 1 to 36 months post-transplant using IFN-γ ELISpot and MHC-peptide tetramers in 28 children who underwent UCBT to treat haematological or inherited disorders. Barely detectable in the first 3 months post-UCBT, antiviral T cell responses directed against CMV and VZV were observed in 30.4% and 40.3% of subjects after 36 months. Four CMV-seronegative subjects developed IFN-γ responses against CMV, and 4 subjects developed VZV-specific IFN-γ responses without clinical signs of VZV infection. No CMV- or VZV-related events were observed in subjects following the development of CMV- or VZV-specific responses >150 SFU per 10E6 PBMC, consistent with T cell-mediated protection. Famciclovir prophylaxis did not strictly prevent the reconstitution of the VZV-specific T cell repertoire. Lastly, the magnitude of VZV- and CMV-specific responses was correlated with the frequency of naïve CD8+ T cells, underlining the importance of immune reconstitution to achieve antiviral protection. Monitoring of cell-mediated immunity during the post-transplant period could guide the tailoring of antiherpetic prophylaxis.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".