Right ventricular remolding, dysfunction, and pulmonary arterial hypertension following left ventricular myocardial infarction (648.7)
Bibliographic record
Abstract
Assessment of cardiac function in patients with heart failure (HF) is generally limited to the evaluation of systolic and diastolic function of the left ventricle (LV). Right ventricle (RV) dysfunction is considered a sequelae of LV HF. However, the pathogenesis of RV remodeling has received little attention. Our objective was to investigate the progression of RV function following LV myocardial infarction (MI). Methods : Left and right ventricle remodeling was assessed using invasive hemodynamics, molecular and histomorphometric approaches at 2, 4 9 and 18 weeks post‐MI induced by permanent ligation of the left anterior descending artery. Results: Invasive hemodynamics revealed a decrease in LV contractility and systolic blood pressure and an increase in end diastolic pressures (EDP), which remained stable until 18 weeks post‐MI. In contrast, RV systolic pressure and contractility initially increased at 2 weeks prior to a drop off from 4 to 18 weeks post‐MI. In addition RV EDP was elevated at all time points. Re‐expression of fetal genes occurred in both ventricles with greater change of several genes in the RV as compared to the LV. Histological analysis revealed significant increases in cardiomyocyte cross sectional area and fibrosis in both LV and RV. Conclusion: Significant RV remodeling and dysfunction is evident immediately following a LV MI and may play an important and underappreciated role in the development of LV HF. Grant Funding Source : Supported by Canadian Institute of Health Research
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".