Acute generalized exanthematous pustulosis from imatinib
Bibliographic record
Abstract
Acute generalized exanthematous pustulosis (AGEP) is rare cutaneous drug reaction involving drug-specific T lymphocytes and neutrophilic inflammation. Imatinib is a tyrosine kinase inhibitor used widely in treatment of chronic myeloid leukemia (CML). Rash is a common side effect of imatinib, occurring in up to 30% of patients. However, there are only two case reports to date describing AGEP secondary to imatinib. A 71-year-old woman known for chronic myeloid leukemia presented with acute onset of generalized pruritus, accompanied by small erythematous papules, and diffuse general edema affecting the face, and upper and lower extremities. The rash developed over a few hours and was associated with shortness of breath, chills, and dysuria. The rash persisted for 14 days at which point a 5 day course of prednisone was prescribed which led to improvement. Imatinib (generic) had been started 3 months earlier; was temporarily interrupted for 2-3 weeks after 1 month; then restarted 2 months prior to onset of the rash. On exam there was pitting edema to lower 2/3 anterior tibia, erythematous papular generalized excoriated rash with xerosis. No blistering, sloughing of skin, target lesions, or pustules. CBC normal, creatinine unremarkable and urine negative for eosinophils. Imatinib (generic) was discontinued and brand name Gleevec ® was started. Two weeks later the rash recurred. Eosinophil count increased to 2.84 x 10 /L. A skin biopsy was arranged which showed parakeratosis containing neutrophils with formation of intracorneal pustules, in keeping with AGEP. Gleevec ® was discontinued and Nilotinib 400mg PO BID was substituted 2 weeks later. The rash resolved and eosinophilia decreased over the next month and has not recurred. AGEP is a rare complication of imatinib therapy, and should be considered in patients who present with atypical rash on imatinib.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".