An Oxygen Transport Model of Human Bone Marrow for Hemolytic Sickle Cell Anemia
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Bibliographic record
Abstract
The human bone marrow (BM) is a complicated tissue with intricate vascular and heterogeneousextravascular (tissue) architecture. Oxygen is an important modulator of differentiation and proliferationof the BM hematopoietic cells under normal and pathological conditions. Currently, due to theinaccessibility of the BM, it is not possible to measure the spatial distribution of the oxygen tension(concentration) levels in the tissue. Thus, the present treatise utilizes mathematical modeling to offer agreater insight on the effects of oxygen on the BM cellular components. Here, we present simulationresults that are correlated with known in vivo data of BM along with proposing a model for the two statedescription of allosteric hemoglobin molecule under hemolytic sickle cell anemia condition of BM.Journal of Chemical Engineering Vol.ChE 24 2006 7-13
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it