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Record W1562215153 · doi:10.1002/9780471462422.eoct065

Quality Assessment Of Clinical Trials

2007· other· en· W1562215153 on OpenAlexaff
David Moher

Bibliographic record

VenueWiley Encyclopedia of Clinical Trials · 2007
Typeother
Languageen
FieldDecision Sciences
TopicMeta-analysis and systematic reviews
Canadian institutionsChildren's Hospital of Eastern Ontario
Fundersnot available
KeywordsStandardizationClinical trialPrincipal (computer security)Quality (philosophy)Randomized controlled trialMedicineProcess (computing)WelfareHealth careComputer sciencePathologyComputer securityEconomicsEconomic growth

Abstract

fetched live from OpenAlex

Abstract Clinical trialists share several similarities with airline pilots. Many of them are investigators (and principal investigators) of large multi‐center randomized controlled trials (RCTs). It is not uncommon for these studies to cost millions of dollars to complete, and they are typically the end stage of a long development process that can easily cost in excess of $100 million dollars. Clinical trialists have often completed advanced training, such as clinical epidemiology, and very definitely have the safety and welfare of trial participants uppermost in their minds. What seems to be missing from the trialist's arsenal is standardization to the process of conducting such studies. More recently, some consensus has developed on how RCTs should be reported, although only a very small percent (2.5%) of the approximately 20,000 health care journals have bought into such reporting standards.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.565
metaresearch head score (Gemma)0.829
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesMetaresearch
DomainCandidate signal: Methods · Consensus signal: Methods
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Methods · Consensus signal: none
Teacher disagreement score0.435
Threshold uncertainty score0.537

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.5650.829
Meta-epidemiology (narrow)0.0030.002
Meta-epidemiology (broad)0.0150.025
Bibliometrics0.0270.032
Science and technology studies0.0020.006
Scholarly communication0.0120.005
Open science0.0060.006
Research integrity0.0040.008
Insufficient payload (model declined to judge)0.0100.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.950
GPT teacher head0.751
Teacher spread0.198 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; the direct Gemma label and the distilled Codex classifier agree on what is shown here.

Study designNot applicable
DomainMethods
GenreMethods

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations3
Published2007
Admission routes1
Has abstractyes

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