Early Predictors of Delayed Neurocardiogenic Syncope in Tilt Table Testing (P1.091)
Bibliographic record
Abstract
OBJECTIVE: To determine early physiologic predictors of delayed neurocardiogenic syncope (NCS) on tilt table testing (TTT). BACKGROUND: TTT is an important investigative tool in diagnosis of orthostatic intolerance and syncope. The duration of TTT varies among various autonomic laboratories, ranging from 10 minutes to 60 minutes. Shorter tilt duration may be associated with higher false negative rates. Although an increase in heart rate of >18/min in the first 6 minutes of tilt may predict delayed syncope other predictive markers are unclear. DESIGN/METHODS: We analyzed early changes in the physiologic variables in consecutive patients who had delayed NCS (after >10 minutes of tilting) and compared them to healthy controls. Fifty-seven patients (23M, 34F; mean age: 36.5 years) with NCS and 24 controls (11M, 13F; mean age: 43.9 years) were included. All patients underwent TTT in our autonomic laboratory with standard AAN protocol, which included 60 minutes of head up tilt at 80° while monitoring EKG and beat-to-beat blood pressure. Cardiac output (CO), pulse pressure (PP), and systolic blood pressure (SBP) oscillations were measured. Total peripheral resistance (TPR) was subsequently calculated. RESULTS: There were significant differences among physiologic parameters in the two groups within 10 minutes of tilting. SBP showed a significant decrease (mean 18 vs. 3 mm of Hg) in the NCS group as compared to controls with reciprocal changes in heart rate (+25 vs. -6/min). During this period mean changes in CO (+100 vs. -400cc); PP (+6 vs. -15mm of Hg); TPR (0.001 vs. -0.003 units) and SBP oscillations (7 vs. 1.2 units) were significantly different in the control and NCS groups, respectively. CONCLUSIONS: Our findings suggest that early changes in physiologic parameters within 10 minutes of tilt can determine predisposition to orthostatic intolerance and delayed NCS. Patients depicting such changes should undergo prolonged TTT to increase its sensitivity Study Supported by:
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".