Incidence and characteristics of vitamin D deficiency rickets in New Zealand children: a prospective New Zealand paediatric surveillance unit study
Why this work is in the frame
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Bibliographic record
Abstract
Vitamin D deficiency rickets is the most significant manifestation of vitamin D deficiency in growing children. Concerns have been raised in New Zealand (NZ), and worldwide, that cases continue to present, and may be possibly increasing. We undertook a prospective study to investigate the incidence and characteristics of vitamin D deficiency rickets in NZ children. Prospective surveillance of Vitamin D Deficiency Rickets was conducted by the NZ Paediatric Surveillance Unit (NZPSU), for 36 months, from July 2010 – June 2013 inclusive. Inclusion criteria were: children aged <15 years with vitamin D deficiency rickets (defined by low 25-hydroxyvitamin D and elevated alkaline phosphatase levels, and/or radiological rickets). 58 children with confirmed vitamin D deficiency rickets were identified. Median age was 1.4 years (range 0.3 – 11), male gender 47%, 95% of children were born in NZ, as opposed to 22% of mothers. Overall annual incidence in those aged <15 years was 2.2/100,000, while incidence in the south of NZ peaked at 6.8/100,000. Overall NZ incidence in children aged <5 years was higher at 6.6/100,000. Skeletal abnormalities, poor growth and developmental delay were the most common presenting features, with hypocalcaemic convulsion in 16%. Key risk factors identified were: dark skin pigment, Indian/South Asian and African ethnicity, age ≤2 years, exclusive breast feeding, and southern latitude, particularly when combined with season (winter/spring). Vitamin D deficiency rickets remains a health problem for New Zealand children, with significant associated morbidity. Public health policy, utilising infant supplementation, for at minimum the above identified risk factors, should be considered to reduce the incidence of this disease among those at high risk.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it