The association between nutritional status and mortality in critically ill children admitted to the pediatric intensive care unit (1024.11)
Bibliographic record
Abstract
Critically ill children requiring mechanical ventilation in pediatric intensive care units (PICUs) are at high risk for mortality. Prior research regarding the impact of nutritional status on morbidity and mortality in PICU patients has been limited to single centers, small populations, or narrowly defined disease groups. We performed a multicenter, international cohort study to determine the unique contribution of nutritional status to mortality risk in mechanically ventilated children in PICUs. Nutritional status of subjects (age 1 month ‐18 years, N=1622) was 17.9% underweight (BMI Z score < ‐2), 54.2% normal weight (BMI Z score > ‐2 and < 1), 14.5% overweight (BMI Z score > 1 and < 2), and 13.4% obese (BMI Z score > 2). The impact of nutritional status on mortality was evaluated using multilevel logistic regression. PICU size and location, admission type, and diagnosis were significantly associated with nutritional status category and used as covariates in the analysis. Compared to normal weight children, the odds ratio for mortality was significantly higher in underweight (OR 1.64; 95% CI 1.23, 2.19; p=.001), overweight (OR 1.67; 95% CI 1.12, 2.50; p=.01), and obese children (OR 1.72; 95% CI 1.10, 2.69; p=.02). Underweight, overweight, and obesity are important risk factors for mortality in PICUs. Longitudinal investigations of nutritional status in critically ill children are warranted. Grant Funding Source : Supported by the Jean Hankin Nutritional Epidemiology award from the Academy of Nutrition and Dietet
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How this classification was reachedexpand
Direct model labels (unvalidated)
Per-model category and study-design labels from the labeling rounds. They are machine output, unvalidated, and the disagreement between models ships as data. No study design here is MEDLINE-validated yet.
| Model arm | Categories | Study design | Confidence |
|---|---|---|---|
| gemma | no category Domain: not available · Genre: Empirical About the Canadian research system: no · About a Canadian topic: no | Observational | low |
| gpt | no category Domain: not available · Genre: Empirical About the Canadian research system: no · About a Canadian topic: no | Observational | low |
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedLabeled directly by 2 models reading the full record.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".