Abstract T MP2: Efficacy of Endovascular Therapy in Acute Ischemic Stroke with Major Artery Occlusion of Anterior Circulation -RESCUE-Japan Registry-
Bibliographic record
Abstract
Background and Purpose: Efficacy of endovascular therapy (EVT) for acute ischemic stroke (AIS) has not been established. In the Japanese nationwide registry study, we aimed to clarify the impact of EVT on outcomes in AIS patients with major artery occlusion of anterior circulations. Methods: In the Recovery by Endovascular Salvage for Cerebral Ultra acute Embolism (RESCUE)-Japan registry, 1442 AIS patients with major artery occlusion within 24 hours after the onset were recruited between July 2010 and Jun 2011. Among them, patients with occlusion of anterior circulation were categorized into 2 groups according to site of occluded arteries: internal carotid artery (ICA) or middle cerebral artery (MCA) M1 proximal occlusion as Group P, and MCA M1 distal, M2 or M3 occlusion as Group D. In each group, we examined the relations between EVT and favorable outcome defined as modified Rankin Scale≦2 at 90days. Results: 482 patients were categorized into Group P (men, 257; mean age,74.6±12.1 years; median baseline National Institute of Health Stroke Scale [NIHSS] score, 18 [IQR 13-22]), and 373 patients were into Group D (men, 204; mean age, 74.2±10.6 years; median baseline NIHSS score, 13 [IQR 7-19]). EVT were performed in 158 patients (32.8%) in Group P and 92 (24.7%) in Group D. In Group P, patients treated with EVT had similar NIHSS score (17.3 vs 17.7) and higher the Alberta Stroke Program Early CT Score on diffusion-weighted imaging (DWI-ASPECTS) on admission (7.4 vs 5.9 P<0.001), and achieved higher rate of favorable outcome (33.5% vs 13.9%, P < 0.001) compared to those without EVT. Whereas in Group D, patients treated with EVT had higher NIHSS (15.0 vs 12.7, P=0.01) and similar DWI-ASPECTS (7.9 vs 7.9), and achieved similar rate of favorable outcome (40.2% vs 45.6%, P=0.40) compared to those without EVT. In a multivariate logistic regression analysis, EVT was related to favorable outcome in Group P (Odds ratio [OR] 2.54, 95% confidence interval [CI] 1.42 - 4.52), but not in Group D (OR 0.74, 95% CI 0.39-1.41). Conclusions: Endovascular therapy can improve the clinical outcome in AIS patients with ICA or M1 proximal occlusion.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".