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Record W1579376059 · doi:10.25011/cim.v30i4.2789

29. The changing concept of aging and the quest for immortality

2007· article· en· W1579376059 on OpenAlexvenueno aff
Daryl J. Wile

Bibliographic record

VenueClinical and investigative medicine · 2007
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetics, Aging, and Longevity in Model Organisms
Canadian institutionsnot available
Fundersnot available
KeywordsImmortalityLife expectancyMythologyLongevityHuman lifeEnvironmental ethicsLegendEPICHistoryAestheticsPhilosophyLiteratureGerontologyMedicineClassicsSociologyArtDemographyArt historyTheologyPopulation

Abstract

fetched live from OpenAlex

The desire to extend human lifespan has spurred scientific and philosophical interest back to the earliest recorded piece of human literature, the Epic of Gilgamesh, which documents the quest of a mythical king to become immortal. In the intervening years between then and now, and particularly in the last century, human lifespan has increased dramatically. Though it is commonly held that there is an upper biological limit to human lifespan, there are some who believe its recent meteoric rise can continue indefinitely. The story of human lifespan has two largely separate prongs: that of the important advances in sanitation, agriculture and medicine that have effected the greatest change in our life expectancy, and the recurring myth, legend and popular beliefs surrounding greatly advanced or eternal human life. In recent years, the myth and science of life expectancy have coalesced, creating a core group of people who believe that immortality is a technically achievable goal. Such claims have muddied the concept of aging such that it is now commonly described as both a disease process and a fundamental part of life. Hackler C. Extending the life span: Mythic desires and modern dangers. HEC Forum, 2006; 16:182-196. Holliday R. Aging is no longer an unsolved problem in biology. Ann. N.Y. Acad. Sci. 2006; 1067:1-9. Rando TA. Stem cells, ageing and the quest for immortality. Nature 2006; 441:1080-1086.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.004
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: Theoretical or conceptual
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.013
Threshold uncertainty score0.034

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0030.004
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.000
Science and technology studies0.0040.017
Scholarly communication0.0040.006
Open science0.0010.003
Research integrity0.0070.007
Insufficient payload (model declined to judge)0.0060.003

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.081
GPT teacher head0.348
Teacher spread0.266 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designTheoretical or conceptual
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2007
Admission routes1
Has abstractyes

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