Cell Growth Regulated by Syndecan-1 in Human Liposarcoma
Bibliographic record
Abstract
Background: The heparan sulfate proteoglycan, syndecan-1 (also known as CD138), is associated with cell proliferation, adhesion, and migration in various types of human malignancies. The role of syndecan-1 in soft tissue tumors is unknown; therefore we examined whether syndecan-1 plays a role in human liposarcoma. Materials and Methods: We performed immunohistochemical analyses of syndecan-1 in 42 liposarcoma cases, including 21 myxoid liposarcoma cases. Recurrence-free survival was estimated by the Kaplan–Meire method. We examined the association between apoptosis and syndecan-1 gene silencing in a human liposarcoma cell line. Results: The proportion of syndecan-1 positive cells (?10%) was significantly associated with unfavorable recurrence-free survival in myxoid liposarcoma patients. There were no significant associations between syndecan-1 expression and prognosis in the other subtypes of liposarcoma. Knockdown of syndecan-1 induced apoptosis and suppression of cell growth in vitro. Conclusion: Syndecan-1 could be a novel prognostic factor for myxoid liposarcoma recurrence and a new therapeutic target for human myxoid liposarcoma.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".