Reduced carotid artery blood flow of spontaneously hypertensive rats is unaffected by aging from 20 weeks (young adulthood) to 65 weeks (upper middle age) (LB690)
Bibliographic record
Abstract
The objective of this study was to quantify blood flow (using a perivascular flowprobe) and pressure (using a catheter‐tip transducer) in the common carotid artery (CCA) of anesthetized young adult (~20 week old) and upper middle aged (~65 week old) Wistar Kyoto rats (WKY) and Spontaneously Hypertensive rats (SHR). In young adult SHR vs. WKY, mean (172±10 vs. 82±2 mmHg), systolic (198±13 vs. 92±4), diastolic (151±9 vs. 72±5), and pulse pressure (48±5 vs. 20±2), and heart rate (371±12 vs. 277±19 beats/min), were each elevated (p<0.01). In SHR, aging had no effect on these pressure parameters, or heart rate; whereas, in WKY, aging was associated with a significant increase in pulse pressure (31±1 mmHg; p=0.04) but no other pressure parameter. Mean (4.94±0.29 vs. 3.80±0.54 ml/min), maximum systolic (11.58±1.08 vs. 19.00±2.18), and minimum diastolic blood flow (0.62±0.73 vs. 1.90±0.34) were each reduced in young adult SHR vs. WKY (p<0.05), while flow pulsatility was no different (3.23±0.73 vs. 3.43±0.44). Aging had no effect on these flow parameters in either SHR or WKY. Together, these data demonstrate that CCA blood flow is >20% reduced in young adult SHR, and that this reduction is neither exacerbated nor attenuated at upper middle age. Given the important contribution of the internal branches of the CCAs to the total perfusion of the brain, these findings may be of pathophysiological and clinical relevance. Grant Funding Source : Supported by NSERC Canada
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".