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Record W1590713986 · doi:10.1002/9780470514962.ch7

Genetics of Obesity in Humans: Current Issues

2007· review· en· W1590713986 on OpenAlexaff
Claude Bouchard

Bibliographic record

VenueNovartis Foundation symposium · 2007
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetic Mapping and Diversity in Plants and Animals
Canadian institutionsUniversité Laval
Fundersnot available
KeywordsHeritabilityGeneticsObesityBiologyQuantitative trait locusPhenotypePositional cloningTraitGenetic linkageLinkage (software)GeneGenetic associationEvolutionary biologyGenotypeEndocrinologySingle-nucleotide polymorphism

Abstract

fetched live from OpenAlex

During the last decade, we have begun to understand some of the reasons why people become obese as assessed by excess body mass for height or excess total body fat content. Obesity frequently aggregates in families. However, this familial resemblance is caused not only by genetic effects but also by lifestyle, and environmental and cultural factors. Thus the genetic heritability of the obesity phenotypes accounts for up to 50% of the age- and gender-adjusted phenotypic variances. These results have been confirmed by overfeeding and negative energy balance studies. The effects of single segregating genes can be detected only under the correct experimental conditions. Most scientists in the area believe that these genes can be identified and that the DNA mutations associated with human obesities will be uncovered. Indeed, association and linkage studies, quantitative trait loci and positional cloning research strategies, and transgenic mouse models are sufficiently promising to suggest that these aims can be achieved. A review of the evidence reported thus far reveals that there are already four loci with strong evidence of linkage with obesity phenotypes in humans.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.996
Threshold uncertainty score0.986

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.075
GPT teacher head0.375
Teacher spread0.299 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations30
Published2007
Admission routes1
Has abstractyes

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