Bibliographic record
Abstract
Abstract HypF is an accessory protein for assembling the NiFe ( CN ) 2 CO active center of [ NiFe ]‐hydrogenases. HypF together with HypE catalyzes the synthesis of the CN ‐ ligands using carbamoylphosphate as the initial substrate. HypF comprises four domains: the acylphosphatase domain, the Zn finger domain, the YrdC ‐like domain with a nucleotide‐binding site and the Kae1‐like “universal domain” with a second nucleotide‐binding site coordinated by a metal. The YrdC ‐ and Kae1‐like domains are juxtaposed with their nucleotide‐binding sites facing each other and sequestered in an internal cavity. The distance between the two sites is approximately 14 Å. The carbamoylphosphate is hydrolyzed to carbamate within the acylphosphatase domain, which then likely migrates through a tunnel in the YrdC ‐like domain toward the ATP molecule bound within this domain's nucleotide‐binding site. The end of the tunnel is near the α‐phosphate of ATP where the carbamate is converted to carbamoyl adenylate intermediate. This intermediate presumably diffuses across the cavity to the nucleotide‐binding site in Kae1‐like domain where the transfer of CN moiety to the C‐terminal cysteine of HypE finally occurs. While the structure discloses the architecture of the various active sites, the details of each catalytic step require further investigations.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.007 | 0.003 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".