Abstract 11698: Pulmonary Hypertension in S100A1 KO Mice is Associated With Endothelial Cell Dysfunction and Impaired eNOS Activation Dependent in Part on the Receptor for Advanced Glycation End-Products (RAGE)
Bibliographic record
Abstract
Background: S100A1, a 10-kDa, Ca 2+ - binding protein is expressed in endothelial cells and its absence is associated with impaired production of nitric oxide (NO) and mild systemic hypertension. As endothelial dysfunction contributes to clinical and experimental pulmonary hypertension (PH), we investigated the impact of deleting S100A1 in knockout mice (KO) on pulmonary hemodynamic and endothelial function. Methods and Results: Under basal conditions in vivo, S100A1 deficient mice exhibited a significant elevation in right ventricular systolic pressure (28.41±3.6 vs.14.9±2.41 mmHg in wild-type (WT), p -4 M increased fluorescence 1.43±0.31-fold vs. 3.91±0.43-fold in WT, p 1177 , by exogenous S100A1 treatment (100nM, 30 min) was 2.19- fold greater in WT vs. KO (p Conclusion: Absence of S100A1 results in PH by disrupting its normal capacity to enhance pulmonary endothelial cell function by induction of eNOS activity and NO levels. The ability of exogenously administered S100A1 to rescue this phenotype mediated by RAGE represents a possible therapeutic target in the treatment of PH.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.008 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".