Omalizumab is effective in the treatment of difficult-to-treat chronic spontaneous urticaria
Bibliographic record
Abstract
Chronic spontaneous urticaria (CSU) is a condition, lasting at least 6 months, where patients experience frequent episodes of red, itchy hives and/or angioedema with no apparent external trigger. For approximately 30-50% of patients this condition can resolve spontaneously but has been known to persist for years. CSU can have a major impact on a patient’s quality of life as it can affect daily activities, sleep, emotional wellbeing and social interactions. In March 2014, omalizumab was approved in Europe and eight other countries for the treatment of CSU in patients with inadequate response to H 1 -antihistamines at approved doses. However, as yet there is no approved indication for its use in CSU in Canada and the US. We report on the effectiveness of omalizumab as a treatment option for difficult-to-treat CSU in our clinic. After receiving a diagnosis of CSU with inadequate response to H 1 -antihistamines, and oral prednisone, patients completed a quality of life (QoL) questionnaire prior to beginning treatment with omalizumab. Patients were requested to complete the QoL questionnaires every two weeks throughout the treatment and, in addition, were monitored closely for clinical response. A total of 10 patients, who started on omalizumab for CSU were evaluated. All were taking H 1 -antihistamines prior to treatment with 8 out of the 10 patients able to decrease or stop the use of H 1 - antihistamines after the 3 dose of omalizumab. The results of the questionnaires indicated a 15% improvement in QoL with an accompanying 18% decrease in the symptom score. Of the 10 patients, 9 indicated an overall improvement in their symptoms while only 6 had an overall improvement in their QoL. Omalizumab is an effective therapy in difficult-to-treat CSU in our tertiary community based allergy and asthma clinic.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".