Immunity Versus Immunopathology in West Nile Virus Induced Encephalitis
Bibliographic record
Abstract
Flavivirus Encephalitis 54 2001). Following the initial subcutaneous or intraperitoneal infection in mice, WNV induces a systemic infection, invades the central nervous system (CNS) and causes death rapidly when encephalitis develops, usually within 1-2 weeks The severity and symptoms of lethal infection observed in mice mimic the symptoms caused by WNV infection in humans. The murine model has been an effective in vivo experimental model to investigate viral pathogenesis and the host immunity in humans. Based on information obtained from studies on animal models, cell culture and patient samples, this review will be focused on discussion of the role of several important immune factors, including pathogen recognition receptor (PRR) -mediated signaling pathways, cytokines, monocytes/microglia, T cells, CD4 + and CD8 + T cells in protection and pathogenesis of WNV-induced encephalitis.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".