Analogs of Glucose-Dependent Insulinotropic Polypeptide With Increased Dipeptidyl Peptidase IV Resistance
Why this work is in the frame
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Bibliographic record
Abstract
Fully and partially DPIV-resistant analogs of GIP1–30 could be synthesized. The introduction of D-amino acids in P1- and P1’-position resulted in a slight reduction in binding and bioactivity. The examined C-terminal truncated fragments (with exception of the GIP1–30 fragment) showed no binding affinity, whereas the antagonistic N-terminal truncated fragments were able to bind to transfected rat GIP receptor. These results emphasize the hypothesis of an existing one-receptor-two-interaction-sites-model which was shown for peptides of the GRF-family. Concerning the potential use of GIP analogs in the treatment of type II diabetes mellitus, these results offer the possibility to synthesize analogs with reasonable half-life times and physiologically relevant binding affinities and bioactivity.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it