Increased positive emotional memory after repetitive transcranial magnetic stimulation over the orbitofrontal cortex
Why this work is in the frame
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Bibliographic record
Abstract
OBJECTIVE: Several studies have demonstrated increased left orbitofrontal cortex (OFC) activity during negative and depressed mood. These mood states have also been associated with reduced memory for positive emotional stimuli. The aim of the present study was to investigate whether slow, inhibitory repetitive transcranial magnetic stimulation (rTMS) over the left OFC would improve memory for positive material. METHODS: We carried out a study with a double-blind, within-subjects design, in which 12 healthy volunteers received 20 minutes of slow rTMS over the left OFC, placebo treatment over the left OFC and rTMS over the left dorsolateral portion of the prefrontal cortex. Effects on memory for fearful and happy faces were investigated. RESULTS: Memory for happy faces was significantly improved after rTMS over the left OFC compared with placebo (t10 = 2.4, p = 0.037). CONCLUSIONS: These findings suggest a role of the OFC in positive emotional memory, which is in accordance with neuroimaging and neuropsychological data. It may be argued that dense projections from the OFC to the limbic emotional circuit are involved in emotional memory and, therefore, play a role in the effects of rTMS that we observed.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it