Modelling and measuring electromechanical coupling in the rat heart
Bibliographic record
Abstract
Tension-dependent binding of Ca(2+) to troponin C in the cardiac myocyte has been shown to play an important role in the regulation of Ca(2+) and the activation of tension development. The significance of this regulatory mechanism is quantified experimentally by the quantity of Ca(2+) released following a rapid change in the muscle length. Using a computational, coupled, electromechanics cell model, we have confirmed that the tension dependence of Ca(2+) binding to troponin C, rather than cross-bridge kinetics or the rate of Ca(2+) uptake by the sarcoplasmic reticulum, determines the quantity of Ca(2+) released following a length step. This cell model has been successfully applied in a continuum model of the papillary muscle to analyse experimental data, suggesting the tension-dependent binding of Ca(2+) to troponin C as the likely pathway through which the effects of localized impaired tension generation alter the Ca(2+) transient. These experimental results are qualitatively reproduced using a three-dimensional coupled electromechanics model. Furthermore, the model predicts that changes in the Ca(2+) transient in the viable myocardium surrounding the impaired region are amplified in the absence of tension-dependent binding of Ca(2+) to troponin C.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".