Abstract W MP109: Childhood Cerebral Sinovenous Thrombosis (CSVT): Long-Term Neuropsychological Outcomes
Bibliographic record
Abstract
Background: Outcome from childhood CSVT particularly in infants is poor. Most studies report “general” neurological outcomes; few describe neuropsychological outcomes specifically. Objectives: To study the spectrum of neuropsychological deficits following childhood CSVT. Methods: Retrospective review of clinical data [incl pediatric stroke outcome measure (PSOM)] & neuropsychological testing (NPT) from 1995-2011 was conducted. NPT included IQ [Wechsler Intelligence Score for Children (WISC-IV), Wechsler Preschool & Primary Scale of intelligence (WPPSI-III)], executive function [Behaviour Rating Inventory of Executive Function (BRIEF)] & attention [Test of everyday attention for children (Tea-Ch)]. Full scale IQ (FSIQ) included verbal comprehension (VCI), perceptual reasoning (PRI), working memory (WMI) & processing speed (PSI) index. Results: NPT was performed in 48/206 subjects. 41 (34 males) were analyzed [excl: cavernous sinus thrombosis (5), prematurity (1), concurrent arterial stroke (1)]. Mean age at NPT: 5.4-y (neonatal CSVT) and 8.5-y (non-neonatal CSVT; mean time from CSVT to NPT 2.4-y). NPT was abnormal (atleast 1SD below mean) in 87% patients in one (29%) or multiple (58%) tests. FSIQ was abnormal in 64% [VCI-69%, PRI-80%, WMI-71%, PSI-79%). Compared to normative population, patients scored significantly lower on FSIQ (p=0.026), VCI (p=0.608), PRI (p= 0.032), WMI (0.124) and PSI (p=0.007). No significant difference was seen in FSIQ between groups [neonates/non-neonates (p=0.827), single/multiple sinus (p=0.2), present/absent parenchymal lesions (p=0.991)]. However males scored significantly lower on FSIQ (p=0.006), PRI (p=0.004), WMI (p=0.002)& PSI (p=0.002)] but not on VCI (0.69)]. BRIEF [metacognition (p=0.061) & executive composite (p=0.095)] & Tea-Ch (p=0.046) scores were also poorer in males. Mean cognitive/behaviour sphere score (max 2.0) of PSOM (assessed closest to NPT) was worse in males (0.41) than females (0.14). Conclusions: Majority of childhood CSVT survivors (males > females) have detectable cognitive deficits on detailed NPT on long term follow-up. NPT is useful in accurate assessment of CSVT outcome & could guide academic interventions. Larger studies are needed to replicate these findings.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".