Genetically Typed Community‐Acquired Methicillin‐Resistant <i>Staphylococcus aureus</i> in a Canadian Hospital
Bibliographic record
Abstract
Genetically typed community-acquired methicillin-resistant Staphylococcus aureus in a Canadian hospitalTo the Editor: Methicillin-resistant Staphylococcus aureus (MRSA) is an important cause of morbidity and mortality in hospital populations (1).The number of MRSA infections that are community-acquired (CA) is increasing in North America, and occurring with greater frequency among individuals who lack the risk profile associated with hospital-acquired (HA) MRSA (2,3).Using pulsed-field gel electrophoresis (PFGE), the National Microbiology Laboratory has identified four strains of S aureus that are responsible for most Canadian CA-MRSA infections: CMRSA10 (USA300), CMRSA7 (USA400), European CA-MRSA and USA1100 (4). methodsA retrospective analysis was conducted of CA-MRSA cases identified using PFGE during a 30-month period at a tertiary teaching hospital in London, Ontario.During this time, all MRSA isolates from patients not known to be previously colonized with HA-MRSA were analyzed with PFGE.Any isolate with a PFGE pattern matching any one of the four National Microbiology Laboratory CA-MRSA strains was considered to be a case.Strain type determined entry into the present study; diagnosis in the community or within 48 h of admission were not inclusion criteria.A case was included in the analysis if the isolate was from a body site that explained the clinical symptoms.Patients with only nasal and/or rectal colonization or CA-MRSA grown in culture with multiple other potential pathogens were excluded from the analysis (n=4).Information on patient characteristics and exposure to risk factors in the past year was abstracted from medical charts.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.004 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.004 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.005 | 0.003 |
| Insufficient payload (model declined to judge) | 0.006 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".