Abstract 3684: Nanoparticle-encapsulated piperine and piperlongumine inhibit breast cancer cell growth and metastatic activity
Bibliographic record
Abstract
Abstract Breast cancer is the second leading cause of cancer-related deaths among women in Canada and the United States. Metastatic disease is the primary cause of death, despite recent advances in breast cancer treatment strategies and personalized medicine. Novel anti-cancer therapeutics are therefore urgently needed to increase the lifespan of breast cancer patients and prevent metastasis. Piperine (PIP) and piperlongumine (PL), two of the major alkaloids in pepper spices, show inhibitory effects on breast cancer cell growth in vivo and in vitro; however, their lipophilicity has restricted possible clinical application. The encapsulation of these phytochemicals in biodegradable nanoparticles is predicted to increase their water solubility and bioavailability. The goal of this study was first, to optimize a method for the preparation of PIP- and PL-containing polymeric nanoparticles, and second, to explore the inhibitory effects of nanoparticle-encapsulated PIP and PL on breast cancer cell growth and metastatic activity. In contrast to the single oil-in-water emulsion method, PIP- and PL-nanoparticles prepared by the thin-film hydration method were more spherical and showed a uniform size distribution. PIP- and PL- containing nanoparticles decreased the viability of MDA-MB-231 and MDA-MB-468 triple-negative breast cancer cells to the same extend as free PIP and PL. In addition, a noncytotoxic concentration of PIP- and PL-containing nanoparticles inhibited the in vitro migration and invasion of triple-negative breast cancer cells. These findings demonstrate that the encapsulation of PIP and PL within polymeric nanoparticles is possible without compromising the bioactivity of these phytochemicals. PIP- and PL-nanoparticles therefore warrant further investigation in mouse models of breast cancer to establish their utility in the treatment of breast cancer. Citation Format: Javad Ghassemi-Rad, David W. Hoskin. Nanoparticle-encapsulated piperine and piperlongumine inhibit breast cancer cell growth and metastatic activity. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 3684. doi:10.1158/1538-7445.AM2015-3684
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".