Tigeciclina versus vancomycin más aztreonam en el tratamiento de infecciones complicadas de piel y tejidos blandos: Experiencia en Latinoamérica
Bibliographic record
Abstract
Introduccion: El tratamiento de infecciones complicadas de piel y tejidos blandos (ICPTB) puede representar un desafio. Se comparo la eficacia de tigeciclina versus vancomicina/aztreonam en pacientes con ICPTB en un estudio multicentrico; este articulo se refiere a la experiencia en Latinoamerica (LA). Metodo: Se asignaron, en forma randomizada, los pacientes a dos grupos de tratamiento: tigeciclina o vancomicina/aztreonam. La meta a evaluar (outcome) primaria fue la curacion clinica, denominada test de curacion (TC). Se establecieron, ademas, metas secundarias y la evaluacion de seguridad del farmaco. Resultados: Un subtotal de 167 pacientes procedentes de LA, de un estudio multinacional que incluyo 573 pacientes, recibieron ≥ 1 dosis del farmaco en estudio. Al TC, los porcentajes de curacion fueron similares entre tigeciclina y vanco-micina/aztreonam en los pacientes clinicamente evaluables). La no inferioridad de tigeciclina no pudo ser demostrada (tamano de muestra insuficiente). Los pacientes tratados con tigeciclina tuvieron mayor incidencia de nauseas, vomitos y anorexia; los pacientes que recibieron vancomicina/aztreonam tuvieron mayor incidencia de prurito y rash. Conclusiones: Los resultados de eficacia en LA fueron consistentes con el estudio multinacional sugiriendo que tigeciclina no es inferior a vancomicina/aztreonam en el tratamiento de pacientes con ICPTB.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.003 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".