Second‐to‐second control of the pressure‐natriuresis mechanism following pharmacological removal of the renin‐angiotensin system (RAS)
Bibliographic record
Abstract
The kidney is a key controller of the long‐term level of arterial pressure (AP), in particular, via pressure‐natriuresis (PN). Increases in renal AP (RAP) directly result in a downstream rise of renal interstitial hydrostatic pressure (RIHP) that is linked to elevated Na + excretion. Though many studies have examined mechanisms and modulators involved in regulating the long‐term control of PN, few have characterized its second‐to‐second control. Thus, the aim was to characterize the acute component of the PN mechanism in vivo before and after pharmacological removal of the RAS. Wistar rats (355 ± 4.4g) were anesthetized (ketamine + thiobutabarbital), and RIHP was determined over a range of RAP using occluder cuffs. The response time for RIHP after a change in RAP was <2 sec. The two treatment groups were: Group 1 ‐ no treatment (n=16) and Group 2 ‐ acute AT 1 R blocker (losartan) treatment (LOS; 10mg/kg/hr iv; n=7). In addition, angiotensin II (Ang II; 250ng/kg) was infused before and after LOS. The RAP‐RIHP relationship was found to be linear over a range of AP (slope = 0.07±0.005). While acute AT 1 blockade lowered RAP (↓30%), surprisingly, the characteristics of the RAP‐RIHP relationship (i.e. slope) were not different from controls. In conclusion, despite causing a depressor response, pharmacological inhibition of the RAS did not alter second‐to‐second control of the RAP‐RIHP relationship. (Funded by CIHR; MK by NSERC)
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".