Hormone use after radiotherapy failure: a survey of Canadian uro-oncology specialists
Bibliographic record
Abstract
Introduction: A survey of Canadian uro-oncology specialists wasperformed to assess practice patterns of patients with recurrentprostate cancer postradiotherapy and to assess the feasibility ofconducting a trial in this setting.Methods: There were 14 survey questions and 1 demographic question.Responses were reported by frequency.Results: There were 96 respondents. Most respondents use bothprostate-specific antigen doubling time (PSAdt) and PSA levelwhen deciding to start androgen deprivation therapy (ADT) inasymptomatic patients. About half of respondents start ADT whenPSA is greater than 10 ng/mL or when the PSAdt is less than6 months. Eighty-six percent felt that the timing of ADT was animportant research question. Over 1500 patients per year wereestimated as being available for such a trial.Conclusion: After radiotherapy failure, respondents initiated ADTabout half of the time when PSA is less than 10 ng/mL and/orPSAdt is less than 6 months. A clinical trial examining the timingof ADT has strong support and appears to be feasible.Introduction : Un sondage mené auprès d’uro-oncologues cana diensa été mené afin d’évaluer les tendances concernant le traitement depatients atteints de cancer récurrent de la prostate après une radiothérapieet d’évaluer la faisabilité d’une étude dans ce contexte.Méthodologie : Le sondage comportait 14 questions portant sur lestraitements et 1 question de type démographique. Les réponsesétaient groupées par fréquence.Résultats : Quatre-vingt-seize médecins ont participé au sondage.La majorité des répondants se basent sur le temps de doublementde l’APS et les taux d’APS pour décider du moment optimal pouramorcer un traitement antiandrogène chez les patients asymptomatiques.Environ la moitié des répondants entreprennent un traitementantiandrogène lorsque le taux d’APS dépasse 10 ng/mL oulorsque le temps de doublement de l’APS est inférieur à 6 mois.Quatre-vingt-six pour cent des répondants ont indiqué que le momentoptimal pour l’amorce du traitement antiandrogène représentaitune importante question de recherche. On estime que plus de1500 patients par année seraient admissibles à une telle étude.Conclusion : Après l’échec d’une radiothérapie, les répondants entreprennentun traitement antiandrogène dans environ la moitié descas lorsque l’APS est inférieur à 10 ng/mL et/ou lorsque le tempsde doublement de l’APS est inférieur à 6 mois. Un essai cliniqueportant sur la détermination du moment optimal pour l’amorce dutraitement antiandrogène est fortement souhaité et semble faisable.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.004 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.004 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".