Anti-Jo1 Antibody in Polymyositis/dermatomyositis Is Still Closely Associated with Lung rather than Joints
Bibliographic record
Abstract
To the Editor: We read with interest the paper by Klein, et al 1 containing detailed data about arthritis in patients with idiopathic inflammatory myopathy (IIM). The authors reported that arthritis was a common feature of IIM that appeared not only at the onset of disease, but also might precede muscular manifestation and occur at any time. Especially noteworthy, 27 out of 29 anti-Jo1–positive patients (93.1%) had arthritis, and this finding led authors to confirm a strong association between arthritis and anti-Jo1. Traditionally, anti-Jo1 is known to be associated with interstitial pulmonary disease and polymyositis (PM)/dermatomyositis (DM), often manifesting the pulmonary symptom. It had occasionally been reported in arthritis in patients with PM/DM, but there were not enough occurrences to treat the relationship with anti-Jo1. In that context, the authors’ 93.1% was an exceptional result considerably distinguished from previous data. We investigated … Address correspondence to Dr. T.Y. Kim, Division of Diagnostic Immunology/Department of Laboratory Medicine, Hanyang University Medical Center, 222 Wangsimni-ro, Seongdong-gu, Seoul, 133-792, Republic of Korea. E-mail: tykim{at}hanyang.ac.kr
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.013 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.002 | 0.003 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.012 | 0.011 |
| Insufficient payload (model declined to judge) | 0.002 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".