Prolonged response to trabectedin in a patient with carcinosarcoma of the ovary refractory to adjuvant platinum-taxane
Bibliographic record
Abstract
Background: Carcinosarcoma of the ovary carries an unfavorable prognosis and the optimal chemotherapeutic regimen for this disease is yet to be determined. To the authors´ knowledge, this is the first report of a metastatic ovarian carcinosarcoma successfully treated with trabectedin monotherapy after failure of platinum/taxane-based therapy. Case report: The case of a platinum-refractory advanced ovarian carcinosarcoma in a 73-year-old female is presented. After initial tumor debulking, the patient received adjuvant carboplatin and paclitaxel. After 2 cycles, tumor progression occurred. The authors speculated that rapid tumor progression occurred as a consequence of regrowth of sarcomatous elements within the carcinosarcoma. This platinum-refractory disease was treated with single-agent trabectedin 1.5 mg/m 2 every three weeks. A prolonged partial response for 13 months along with an acceptable safety profile was achieved. During this time, the patient was able to perform her daily activities without restrictions. Conclusion: Our case suggests that trabectedin monotherapy may represent a viable therapeutic option for patients with platinum-refractory advanced ovarian carcinosarcoma.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".