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Record W1780931260 · doi:10.1016/s0140-6736(15)00308-6

Efficacy, safety, and tolerability of augmentation pharmacotherapy with aripiprazole for treatment-resistant depression in late life: a randomised, double-blind, placebo-controlled trial

2015· article· en· W1780931260 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
fundA Canadian funder is recorded on the work.

Bibliographic record

VenueThe Lancet · 2015
Typearticle
Languageen
FieldMedicine
TopicTreatment of Major Depression
Canadian institutionsUniversity of TorontoCentre for Addiction and Mental Health
FundersTaylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine in St. LouisNational Center for Advancing Translational SciencesNational Institute of Mental HealthNational Heart, Lung, and Blood InstituteNational Center for Complementary and Integrative HealthNational Center on Minority Health and Health DisparitiesNational Institute on AgingNational Institutes of HealthH. Lundbeck A/SCanadian Institutes of Health ResearchCentre for Addiction and Mental Health FoundationAmerican Foundation for Suicide PreventionFondation Brain CanadaUniversity of TorontoCarnegie Mellon UniversityInstitute of Clinical and Translational SciencesCentre for Addiction and Mental HealthUniversity of PennsylvaniaCampbell Family Mental Health Research InstituteRocheBristol-Myers SquibbJohn A. Hartford FoundationBrain and Behavior Research FoundationUniversity of PittsburghNational Palliative Care Research CenterWake Forest UniversityCommonwealth of Pennsylvania
KeywordsAripiprazolePlaceboTolerabilityMedicineClinical endpointDepression (economics)Montgomery–Åsberg Depression Rating ScaleRandomized controlled trialInternal medicinePharmacotherapyAdverse effectPsychiatryPhysical therapyMajor depressive disorderMoodSchizophrenia (object-oriented programming)Alternative medicine

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.012
Threshold uncertainty score0.397

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.072
GPT teacher head0.359
Teacher spread0.287 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it