Assessing the efficacy of long-term administration of Tolfenamic acid in dogs undergoing femoral head and neck excision
Bibliographic record
Abstract
Summary Femoral head and neck excision (FHNE) is a salvage procedure routinely performed when severe osteoarthritis is present and clinical signs cannot be managed by conservative treatment, or when total hip replacement is cost prohibitive for the owners. The purpose of the study reported herein was to evaluate the adverse effects and efficacy of long-term administration of Tolfenamic acid in dogs undergoing FHNE. Twenty dogs admitted with clinical signs associated with bilateral hip degenerative joint disease and weighing more than 20 kg were included in the study. Ten dogs received Tolfenamic acid for four months following FHNE and 10 dogs received a placebo. At four months after surgery, the placebo group had a significant decrease, compared with pre-operative values, in peak vertical force (PVF) (60.38% BW vs 64.77% BW, p = 0.046), and a significant decrease in vertical impulse (VI) (8.38% BW x sec. vs 9.64% BW x sec., p = 0.023). There was not any significant difference between pre- and post-operative results in the Tolfenamic acid group regarding PVF (65.13% BW vs 63.31% BW, p = 0.296) and VI (8.24% BW x sec. vs 8.71% BW x sec., p = 0.945). A significant difference was not found between the two groups with regard to endoscopic evaluation of mucosal lesions. Subjectively, the owners of the dogs in the Tolfenamic acid group reported an earlier use of the limb, a more compliant dog during physical therapy and a more rapid return to a ‘normal’ gait. Long-term administration of Tolfenamic acid may therefore be recommended, following FHNE, to improve the results of the operation.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".