A Preliminary Investigation of Cardiac Stem/Progenitor Cells in the Lizard Heart
Bibliographic record
Abstract
Resident stem/progenitor cell populations have been identified within many vertebrate tissues, including the hearts of teleost fish, urodeles, and mammals. Although often rare, these populations are considered crucial for normal physiological repair, and may also play a role in tissue regeneration. Here we provide preliminary evidence of the presence of resident cardiac stem/progenitor cells within the lizard Eublepharis macularius (the leopard gecko). Using Proliferating Cell Nuclear Antigen (PCNA) immunostaining, we determined that gecko cardiomyocytes continue to proliferate into adulthood. Next, we performed a 5‐bromo‐2'‐deoxyuridine (BrdU) pulse‐chase experiment to identify slow cycling cells within the normal (uninjured) heart. We found BrdU label‐retaining cells within cardiac tissues chased for 4, 6 and 20 weeks within the epicardium and myocardium of the ventricular wall and trabeculae, indicating that quiescent or slow‐cycling cells are present. Finally, we observed that select BrdU label‐retaining cells at 20 weeks were also immunopositive for the cardiac progenitor marker c‐kit. Based on these findings, we predict that putative cardiac stem/progenitor cells are present in the gecko heart.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".